China (Mainland)
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Manufacturer Supplies supplement high-quality CMS121 powder 98% purity min. CAS NO.1353224-53-9
- Min.Order: 1 Metric Ton
- Payment Terms: T/T,Other
- Product Details
Keywords
- 1353224-53-9
- high-quality CMS121 powder
- Manufacturer Supplies supplement high-quality CMS121 powder
Quick Details
- ProName: Manufacturer Supplies supplement high-...
- CasNo: 1353224-53-9
- Molecular Formula: C20H19NO3
- Appearance: Solid
- Application: Dietary supplements, supplements, Nut...
- DeliveryTime: about ten days
- PackAge: 1kg/bag，25kg/drum
- Port: shanghai
- ProductionCapacity: 100 Kilogram/Week
- Purity: 98%
- Storage: Store in a well-closed and dry place w...
- Transportation: Express/Air/Sea
- LimitNum: 1 Metric Ton
- Heavy Metal: ≤10ppm
- Valid Period: 2year
- Grade: Food Grade
Superiority
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Product name |
CMS121 |
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Other name |
CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
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CAS No. |
1353224-53-9 |
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Molecular formula |
C20H19NO3 |
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Molecular weight |
321.37 |
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Purity |
98.0% |
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Appearance |
Solid |
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Application |
Dietary Supplement Raw Material |
Features
(1) Effective activity: CMS-121 has strong pharmacological activity as an inhibitor of acetyl-CoA carboxylase 1 (ACC1). Its potent inhibitory effect on ACC1 makes it a promising compound for various therapeutic applications.
(2) Neuroprotective effect: CMS-121 exhibits significant neuroprotective properties and protects HT22 cells from ischemia and oxidative damage. This neuroprotective activity suggests its potential in the treatment of neurological disorders characterized by such injuries.
(3) Anti-inflammatory activity: CMS-121 exhibits significant anti-inflammatory effects, indicating its ability to regulate inflammatory responses. This property opens up the possibility of treating inflammatory diseases, where modulation of inflammation is crucial.
(4) Antioxidant activity: CMS-121 has strong antioxidant activity and can resist damage caused by oxidative stress. This antioxidant capacity has the potential to address diseases associated with oxidative stress.
Application
CMS-121 is a quinolone derivative and orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor with promising pharmacological properties. Extensive research has been conducted to investigate the potential benefits of CMS-121 in various areas, including neuroprotection, anti-inflammatory effects, antioxidant activity and its effects on aging-related markers. This compound shows great potential as a therapeutic agent for the treatment and prevention of neurological disorders, cognitive decline, and age-related diseases.
Details
Product introduction
In studies conducted on HT22 cells, CMS-121 has demonstrated significant neuroprotective effects. It effectively protects these cells from ischemia and oxidative damage. The ability of CMS-121 to protect neuronal cells suggests its potential in combating ischemic diseases and oxidative stress-induced neurological disorders. Additionally, CMS-121 exhibits significant anti-inflammatory properties, indicating its ability to modulate inflammatory responses. By doing so, CMS-121 has the potential to reduce inflammation in various tissues and organs, potentially treating inflammatory diseases. Additionally, CMS-121 has potent antioxidant activity that can counteract damage caused by oxidative stress. Preliminary studies in rapidly aging SAMP8 mice show promising results with CMS-121. Oral administration of CMS-121 over 4 months reduced cognitive decline, improved metabolic markers, and attenuated transcriptional markers associated with brain aging. Additionally, CMS-121 was found to maintain mitochondrial homeostasis by regulating acetyl-CoA metabolism.